Inflammation. Disc Degeneration. There is a connection.
Inflammation acts as the body’s response system to damaging
stimuli (injury, pathogens, metabolic stress – a disc herniation pushing
on a nerve!) as it tries to repair itself
before the harm was achieved. The Chiropractic TRUhealthDR is always amazed at what the body can do!
The Chiropractic TRUhealthDR sees its Colorado Springs chiropractic care as a partner of
the body’s system in healing particularly
when there is spine pain. Chiropractic care uses
many tools like spinal manipulation, exercise, and nutrition to help
the body. Melatonin is one nutritional tool that is proving value
in its ability to interrupt the inflammatory process
related disc herniation that results
in back pain, neck pain and other spine related pain.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6
(IL-6) and tumor necrosis factor-α (TNF-α) are related
to intervertebral disc degeneration. (1) IL-1 β actually promotes
itself, its own expression, by upregulating NLRP3 inflammasome activation. (2)
The body regulates itself down to the cellular level
via autophagy, the natural process during which the body’s
cells clear out damaged (ie, by inflammation) or unneeded parts. In
a new study, melatonin boosted autophagy
and reduced the degradation of the disc’s
extracellular matrix (technically marked by a decline
in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB
signaling pathway). The end conclusion was that melatonin inhibits
intervertebral disc degeneration by promoting autophagy. (3)
Wow. The Chiropractic TRUhealthDR is inspired by this research to see just
how well melatonin can work for Colorado Springs back pain related
to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common malady
seen at The Chiropractic TRUhealthDR that positive news of
melatonin’s benefits are quite exciting. A new
study explained how melatonin could modify
the extracellular matrix of the disc remodeling process started
by IL-1 β. Additionally, melatonin reduced the
inflammatory cell collection and reduced the release of connected
inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding
that melatonin interrupted the IL-1B feedback loop, researchers
postulated that melatonin may support
the restoration process of intervertebral discs after damage has already been done. (1) The Chiropractic TRUhealthDR continues
following the new research regarding the role inflammation plays
in Colorado Springs disc degeneration and melatonin’s role in tackling
INFLAMMATION AND MELATONIN
The significance of melatonin in assisting
to slow or stop painful conditions due to inflammation is rising.
The description of melatonin as a multitasking molecule influencing
mood, immunity, and energy among other things is quite fitting.
It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically
by blocking the activation of inflammasomes (4) Melatonin’s
formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine.
The pineal gland secretes melatonin naturally. Melatonin impacts
the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy
(cell-cleanout) processes. (1) Melatonin’s specific effect on
inflammation and disc degeneration is most attention-getting
to The Chiropractic TRUhealthDR and our Colorado Springs back pain patients.
CONTACT The Chiropractic TRUhealthDR
Listen to this PODCAST
with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different
from any other country on The Back Doctors Podcast with Dr.
Michael Johnson as she describes how The Cox® Technic
System of Spinal Pain Management addresses disc
degeneration for relief of chronic low back pain in her patient.
Schedule your Colorado Springs chiropractic appointment with
The Chiropractic TRUhealthDR now. We can talk about the role
inflammation plays in your back pain experience and how melatonin may address the related disc